Alligevel er smertestillende midler den hyppigste årsag til akut forgiftning herhjemme, ligesom du ved et overdrevent forbrug above tid risikerer alvorlige bivirkninger som både mavesår og leverskader.Fra gammel tid har male anvendt udtræk fra opiumsvalmuen i smertebehandling og disse midler er baseret på naturlige opioider eller de er kunstig
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